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Coronavirus RNA structures?

Bioinformatics Asked on August 26, 2021

Is there anything known about the RNA structures of coronaviruses? More specifically – do they have any interesting known structures in the translatable region, like RRE of HIV or the double loops in flaviviruses?

Update
Here is a recent development on the side of structure prediction.

One Answer

To add a more complete answer: the current coronavirus is closely related to the SARS virus that caused the outbreak in 2004, and on which much research has been done.

Here is a general review of the coronavirus epidemiology, life cycle etc.

I haven't found yet any materials about the RNA structures in the translatable region, however the structures in the 3' and 5' terminal regions are well studied and are known to be crucial for initiating viral replication and for its packaging.

This recent article addresses in details the RNA structures in 5' terminal of human coronaviruses, whereas this older article describes the structures both in 3' and 5' terminals.

Finally, the interesting algorithmic developments for the link that I added to the question are described here.

Answered by Roger Vadim on August 26, 2021

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