How are the scores of GeneSplicer, MaxEntScan and SpliceRegion interpreted from VEP annotations?

Bioinformatics Asked by Law on February 20, 2021

I am using VEP from Ensembl to annotate my VCF files with the extra plugins of GeneSplicer, MaxEntScan and SpliceRegion. However, I don’t fully understand the output of these scores.

I know that they are used for splicing predictions on trained sets.

What are the range of these values ?
What does a high or low value mean ?
What is the threshold ?

Can someone please explain them please ?

ensembl machine learning

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