How to interpret UniProt allele patterns?

Bioinformatics Asked by Guy Coder on October 1, 2021

In creating a parser for the UniProt flat file uniprot_sprot.dat (directory) in the manual for the comments POLYMORPHISM there are listed patterns for alleles, e.g. for 1A11_HUMAN is

The following alleles of A-11 are known:
A*11:01 (A-11E), A*11:02 (A-11K), A*11:03, A*11:04, A*11:05 and A*11:07.

I tried searching for a description of the patterns using the words allele and/or polymorphism and found nothing.

  • How are the allele patterns to be interpreted?
  • Is there a search term to be used when looking for the patterns?
  • Also, is there an official repository of the alleles?

The answer does not have to explain the specifics of the example given.

Example of explanation of other allele pattern from here

enter image description here

This explanation of the patterns doesn’t explain the part of the pattern in UniProt like (A-11E).

One Answer

These are cytotoxic T-cell HLA alleles. HLA genotyping is very common and easy to do, so Genbank is the repository.

A*11:01 has very high frequency in Aborigine populations here . You can explore the population genetics and the past, present and current population genetics distributions per population of HLA at

Answered by M__ on October 1, 2021

Add your own answers!

Related Questions

NO_COOR reads not in a single block at the end 0 -1

1  Asked on May 19, 2021 by user9393


MUMmer plot error. Line 884. What to do?

0  Asked on May 18, 2021 by dansterboy


Is there public RESTful api for Gnomad?

5  Asked on May 14, 2021 by pasted


nextflow: Filter outputs of a process

1  Asked on May 10, 2021 by zillur-rahman


Filtering VEP annotation file

1  Asked on May 10, 2021 by jeni


Ask a Question

Get help from others!

© 2023 All rights reserved. Sites we Love: PCI Database, MenuIva, UKBizDB, Menu Kuliner, Sharing RPP, SolveDir