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How do Helper T cells activate Cytotoxic T cells?

Biology Asked by Chemo-Mike on January 18, 2021

Helper T cells activate the Antigen-presenting Cells (APCs) through their secretions (the cytokines) (although the T cell in question gets activated in turn). This is typically achieved by cell-to-cell contact using receptors on both the helper T
cell and APC.
Since Helper T cells also activate Cytotoxic T
cells, I am particularly interested in knowing whether cell-to-cell contact occurs between these two T cell subtypes (as is the case in helper T cell – APC communication).

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