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Factors given by DoE can experimentally not be reached

Cross Validated Asked on November 24, 2021

We are running a DoE in a CCD manner at the moment.
One factor is quite difficult to reach and to reproduce: Humidity because it has to be set by chemical reactions.
To be more concise: The factor 56 % relative humidity can only be reached with 44 % relative humidity and some +/- % to reproduce it.

How to deal with that? My suggestion is to ignore that and kind of cheat the measurements by using the value 56 % for all the values which should be 56 %. I’d do this because in my understanding of the DoE it is less the value itself but more the factor that will be used. Sure, they are connected but in real experiments you will never be able to achieve all factors without any deviation.
Any advice?

The values are given here:

Values

A = H2 concentration
B = CO concentration
C = C2H2 concentration
D = Environment temperature
E = relative humidity

I can also ask for the actual DoE plan with all single measurement points? At the moment, I only receive the measured data on a dripping periodicity, so the first data points are not revealing the DoE. But I can ask for the plan.

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