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How Much Lamotrigine Is an Overdose?

Question Asked by Andre B. Weaver on August 12, 2022

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In adults with a serum concentration >25 mg/L, severe toxicity may occur. In patients ≤3.5 years of age, ingestions of ≥525 mg may produce severe CNS depression and seizures.

Can you OD from lamotrigine?

Even though lamotrigine has been reported to be well tolerated, there is a risk of toxic effects which can be life threatening in overdose. This needs to be borne in mind when prescribing to patients at an increased risk of deliberate drug overdose.

What is a toxic level of lamotrigine?

A high (potentially toxic) lamotrigine level was defined as greater than 14.0 mg/L. This threshold was chosen based on the proposed reference range of 3.0–14.0 mg/L, and published literature showing increased risk of toxicity above 14.0 mg/L [1,2,18].

Is 500 mg of Lamictal too much?

The recommended maintenance dose of LAMICTAL as monotherapy is 500 mg/day given in 2 divided doses. To avoid an increased risk of rash, the recommended initial dose and subsequent dose escalations for LAMICTAL should not be exceeded [see BOX WARNING].

What happens if I take too much lamotrigine?

The most common clinical effects arising from lamotrigine overdose are drowsiness and lethargy, vomiting, nausea, ataxia, nystagmus, dizziness/vertigo, and tachycardia.

Is 600 mg of Lamictal too much?

After this, your doctor may gradually increase your dose as needed. However, the dose is usually not more than 600 mg a day.

Is 400 mg of Lamictal too much?

However, the dose is usually not more than 400 mg a day. Adults and children older than 13 years of age taking valproic acid (Depakote®)—At first, 25 mg of lamotrigine once every other day for 2 weeks, then 25 mg once a day for 2 weeks. After this, your doctor may gradually increase your dose as needed.

Does Lamictal cause hypersexuality?

Conclusions: Lamotrigine may cause drug-related hypersexuality by an unclear underlying mechanism.

What drugs should not be taken with Lamictal?

Does Lamictal cause weight gain?

Unlike most mood stabilizers, though, Lamictal is less likely to cause weight gain. In clinical trials, less than 5 percent of those taking Lamictal gained weight. If you take Lamictal and have gained weight, the weight gain may be an effect of the disorder itself.

Is 700 mg of Lamictal too much?

LTG pharmacokinetics were linear over the range of 500-700 mg/day. Conclusions: LTG doses < or = 700 mg/day can be tolerated in patients receiving concomitant enzyme-inducing AEDs.

What does lamotrigine do to the brain?

Lamotrigine, acts through several molecular targets and overcomes the major limitation of other conventional antidepressants by stabilizing mood from “below baseline” thereby preventing switches to mania or episode acceleration, thus being effective for bipolar I disorder.

Does lamotrigine shorten your life?

Using Drosophila as our model system, we found that lamotrigine decreased mortality and increased lifespan in parallel with a reduction in locomotor activity and a trend towards metabolic rate depression.

What happens if you overdose on bipolar medication?

Symptoms of lithium toxicity include severe nausea and vomiting, severe hand tremors, confusion, and vision changes. If you experience these, you should seek immediate medical attention to check your lithium levels.

Can too much lamotrigine cause depression?

Lamotrigine can worsen depression and even provoke suicidality.

What happens if you drink on Lamictal?

lamoTRIgine food

Alcohol can increase the nervous system side effects of lamoTRIgine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with lamoTRIgine.

How does lamotrigine make you feel?

Lamotrigine may make you feel very drowsy or sleepy when you start taking it. It may also make it difficult for you to get to sleep. If these symptoms carry on for a long time, or if this is difficult for you, talk to your doctor or pharmacist about other medicines you could take.

References

  1. https://journals.sagepub.com/doi/10.1177/2045125316656707
  2. https://www.sciencedirect.com/science/article/pii/S2214750021001566
  3. https://www.rxlist.com/lamictal-drug.htm
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765213/
  5. https://www.mayoclinic.org/drugs-supplements/lamotrigine-oral-route/proper-use/drg-20067449
  6. https://www.mayoclinic.org/drugs-supplements/lamotrigine-oral-route/side-effects/drg-20067449?p=1
  7. https://pubmed.ncbi.nlm.nih.gov/16473556/
  8. https://www.nami.org/About-Mental-Illness/Treatments/Mental-Health-Medications/Types-of-Medication/Lamotrigine-(Lamictal)
  9. https://www.healthline.com/health/bipolar-disorder/lamictal-weight-gain
  10. https://pubmed.ncbi.nlm.nih.gov/8814098/
  11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615936/
  12. https://pubmed.ncbi.nlm.nih.gov/19430925/
  13. https://www.webmd.com/bipolar-disorder/what-to-know-about-lithium-toxicity
  14. https://www.singlecare.com/blog/lamotrigine-side-effects/
  15. https://www.drugs.com/food-interactions/lamotrigine,lamictal.html
  16. https://www.youngminds.org.uk/young-person/medications/lamotrigine/

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