Players with 300 or more goals for a single team in top flight domestic league (European clubs)

I have started a CW answer, where various users can add players they find (or occasionally update numbers for active players). I guess in this way we can find at least an approximation of a complete list.

We could get very different numbers depending on which competitions we count (for example, all competitions including European cups, all domestic competitions including domestic cups and lower level leagues). To make this list correspond to the OP, let us only count top-level domestic leagues. (I.e., we don't count cups, only league matches in the top-level league.)

Players with 300 or more goals for a single team in top flight domestic league (European clubs)

1. Lionel Messi (Barcelona/La Liga) 449¹
   
2. Uwe Seeler (Hamburger SV/Oberliga & Bundesliga) 404²
3. Jimmy McGrory (Celtic Glasgow/Scottish League) 395³
4. Josef Bican (Slavia Prague/Czechoslovak First League) 395⁴
5. Ferenc Szusza (Újpest/Hungarian League) 393
6. Gyula Zsengellér (Újpest/Hungarian League) 368
7. Gerd Müller (Bayern Munich/Bundesliga) 365
8. Ferenc Puskás (Budapest Honvéd/National Championship I) 352
9. Albert De Cleyn (KV Mechelen/Belgian First Division) 350⁶
10. Joseph Mermans (Anderlecht/Belgian First Division) 339
11. Fernando Peyroteo (Sporting/Primeira Liga) 329⁶
12. Eusébio (Benfica/Primeira Divisão) 317
13. Cristiano Ronaldo (Real Madrid/La Liga) 311
14. Dixie Dean (Everton/First Division) 310⁷
15. Willy van der Kuijlen (PSV Eindhoven/Eredivisie) 308

Players marked in bold still play in the given club and competition.

¹As of 14 December 2020
²404 goals for Hamburger SV, if we count both Oberliga and Bundesliga; 137 if we only count Bundesliga. (Oberliga was the highest level competition in the North of Germany before the foundation of Bundesliga.)
³395 according to stats at Wikipedia, 397 according to RSSSF.
⁴The number 395 is from Wikipedia. RSSSF lists separately 218 goals in Czechoslovak competitions and 232 goals in the era of Protectorate of Bohemia and Moravia. His stats at RSSSF are not broken down by the team, only total number of goals is given.
⁵377 according to Albert De Cleyn Wikipedia page, 350 according to RSSSF and Belgian Pro League Wikipedia page.
⁶330 according to RSSSF.
⁷308 according to RSSSF.

Sources

• Wikipedia articles about individual players
• List of League All-Time Topscorers at RSSSF
• Top 10 Goalscorers in Bundesliga History
• Das große Buch der Fußball-Rekorde by Omar Gisler, page 40
• Wikipedia article on Belgian Pro League and and RSSSF Archive
• Top Division English League Goal Scorers 1888-2015
• England - All-Time Topscorers at RSSSF
• Portugal - All-Time Topscorers at RSSSF
• Scotland - All-Time Topscorers at RSSSF
• Hungarian league top scorers at Wikipedia nad RSSSF
• Spanish football top scorers at Wikipedia
• The top scorers in European league history at uefa.com
• Meet Europe's most prolific scorer of all time at uefa.com
• Lionel Messi breaks into top 10 all-time scorers list for Europe's top leagues... - Daily Mail
• Greatest goalscorers of individual clubs at Footyroom forum.
• World Best As per IFFHS at Xtratune forum.
• The 'Messis' from the world's best leagues at marca.com
• The top scorers in European league history - UEFA (Internet Archive)