How to get rid of "this script contains malicious content" error?

I’ve made a VB script for my startup procedure in Windows 10 that launches an executable. It uses the following structure:

Dim Host
Set Host = CreateObject("WScript.Shell")
Host.Run "MyExecutable.exe 'parameter'", 0

After a recent update a couple weeks ago, I started getting this window on startup:

Script:
Pathtoscript.vbs
Line: 6
Char: 1
Error: This script contains malicious content and has been blocked by your antivirus software.: 'Run'
Code: 800A802D
Source: Microsoft VBScript runtime error

As expected, there is an issue with running the necessary command via Host.Run "MyExecutable.exe 'parameter'", 0

I tried signing the script, but this didn’t help, even though the signature is valid and the key is accepted by my system. What can I do to make it work?